Construction of calibration curve for premature chromosome condensation assay for dose assessment
نویسندگان
چکیده
منابع مشابه
Construction of Calibration Curve for Premature Chromosome Condensation Assay for Dose Assessment
Cytogenetic dosimetry plays an important role in the triage and medical management of affected people in radiological incidents/accidents. Cytogenetic biodosimetry uses different methods to estimate the absorbed dose in the exposed individuals, and each approach has its advantages and disadvantages. Premature chromosome condensation (PCC) assay presents several advantages that hopefully fulfill...
متن کاملConstruction of a dose – response curve by induction of premature chromosome condensation for biological dosimetry
Premature Chromosome Condensation (PCC) appears to have a possible utility for biological dosimetry purposes. The PCC technique may be adapted for cases of suspicion of overexposure where sampling is performed at least one day after an accident. For this purpose, human blood samples were exposed in vitro to 60Co up to 10 Gy and the PCC technique was performed immediately after irradiation. Anal...
متن کاملconstruction of a dose – response curve by induction of premature chromosome condensation for biological dosimetry
premature chromosome condensation (pcc) appears to have a possible utility for biological dosimetry purposes. the pcc technique may be adapted for cases of suspicion of overexposure where sampling is performed at least one day after an accident. for this purpose, human blood samples were exposed in vitro to 60co up to 10 gy and the pcc technique was performed immediately after irradiation. anal...
متن کاملBiological Dose Assessment by Chemical Induction of Premature Chromosome Condensation
Dose assessment of radiation victims is a key element in medical management of radiation accidents. At high radiation doses (> 6 Gy), dicentric assay lose its efficiency and premature chromosome condensation (PCC) assay was proposed to overcome the restrictions of dicentric assay. It was shown that PCC ring is more suitable and simpler than dicentric for biodosimetry in high radiation doses. In...
متن کاملInduction of premature chromosome condensation (PCC) by calyculin A for biodosimetry
Background: Premature chromosome condensation (PCC) is a method for interphase chromosome analysis in biodosimetry. This study was performed to verify the usefulness of PCC induced by calyculin A in human peripheral blood lymphocytes (pbl) for biological dosimetry and possible construction of dose-response curve. Materials and Methods: Peripheral blood was obtained from a healthy donor and expo...
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ژورنال
عنوان ژورنال: Genome Integrity
سال: 2016
ISSN: 2041-9414
DOI: 10.4103/2041-9414.197166